منابع مشابه
Excipients and their role in absorption: Influencing bioavailability of cyclosporine by triglycerides and polyglycerol esters.
AIMS The goal of the experiment was to verify bioavailability of immunosuppressive drug cyclosporine after oral administration, to determine, in particular, effect of triglycerides and polyglycerol esters on bioavailability of this lipophilic, poorly soluble drug. METHODS 1) Absorption of cyclosporine A from soya oil and polyglycerol-3-oleate was tested after intra-duodenal application to rat...
متن کاملPreparation and characterization of β-carotene nanodispersions stabilized by polyglycerol esters of fatty acids using solvent displacement technique
The effects of six different polyglycerol esters of fatty acids (PGEs) as nonionic emulsi fiers on the physicochemical properties and stability of β-carotene nanoparticles in oil-in-water dispersions prepared by solvent displacement technique were investigated. The β-carotene particle size was measured by a laser diffraction technique, and the stability and retention of β-carotene during storag...
متن کاملPolyglycerol-opioid conjugate produces analgesia devoid of side effects
Novel painkillers are urgently needed. The activation of opioid receptors in peripheral inflamed tissue can reduce pain without central adverse effects such as sedation, apnoea, or addiction. Here, we use an unprecedented strategy and report the synthesis and analgesic efficacy of the standard opioid morphine covalently attached to hyperbranched polyglycerol (PG-M) by a cleavable linker. With i...
متن کاملthe effect of the utilization of electronic dictionaries on depth and breadth of vocabulary knowledge: a case of iranian efl learners
مطالعه حاضر تلاشی است برای بررسی تأثیرات به کارگیری فرهنگ لغات ، یکی از مهمترین ابزارهای یادگیری واژگان درفراگیری زبان خارجی، بر روی دانش لغوی. دراین تحقیق فرهنگ های الکترونیکی در قیاس با فرهنگ های چاپی مورد بررسی قرارگرفته اند که آیا این فرهنگ ها تاثیرقابل توجهی بر روی دوبعد کمی و کیفی دانش لغوی یعنی عمق و گستره لغات می گذارند. همچنین مشخص گردیده است که آیا تفاوت قابل ملاحظه ای میان عمق و گستر...
15 صفحه اولEffect of okadaic acid on utilization of lipoprotein-derived cholesteryl esters by rat steroidogenic cells.
This study examines various functional, biochemical, and structural changes in rat adrenocortical and ovarian granulosa cells that could account for the decline in lipoprotein-supported hormone production after cell treatment with the protein phosphatase inhibitor, okadaic acid. Although the steroidogenic pathway enzymes in these cells are not in themselves affected by okadaic acid, the intrace...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1938
ISSN: 0306-3283
DOI: 10.1042/bj0321938